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Org Lett. 2014 May 2;16(9):2334-7. doi: 10.1021/ol500587m. Epub 2014 Apr 10.

Cooperative catalysis by palladium-nickel binary nanocluster for Suzuki-Miyaura reaction of ortho-heterocycle-tethered sterically hindered aryl bromides.

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  • 1Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER) , Sector 67, S. A. S. Nagar 160 062, Punjab, India.


The palladium-nickel binary nanocluster is reported as a new catalyst system for Suzuki-Miyaura cross-coupling of ortho-heterocycle-tethered sterically hindered aryl bromides. The inferior results obtained with the reported Pd/Ni salts/complexes or individual Pd/Ni nanoparticles as catalyst reveal the cooperative catalytic effect of the Pd and Ni nanoparticles in the Pd-Ni nanocluster. The broad substrate scope with respect to variation of the 2-arylbenzoxazole moiety and boronic acids, which offers a means for diversity generation and catalyst recyclability, marks a distinct advantage.

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