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J Gen Virol. 2014 Jul;95(Pt 7):1436-43. doi: 10.1099/vir.0.060764-0. Epub 2014 Apr 9.

Sunguru virus: a novel virus in the family Rhabdoviridae isolated from a chicken in north-western Uganda.

Author information

  • 1Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, 3156 Rampart Rd, Fort Collins, CO 80521, USA jledermann@cdc.gov Apowers@cdc.gov.
  • 2International Centre for Diarrheal Diseases Research, Bangladesh, 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh.
  • 3Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, 3156 Rampart Rd, Fort Collins, CO 80521, USA.
  • 4Department of Arbovirology, Uganda Virus Research Institute (UVRI), PO Box 49, Entebbe, Uganda.
  • 5CDC Uganda Plaque Laboratory, Uganda Virus Research Institute (UVRI), Arua, Uganda.
  • 6Vurra Subcounty Local Government, Arua, Uganda.

Abstract

Sunguru virus (SUNV), a novel virus belonging to the highly diverse Rhabdoviridae family, was isolated from a domestic chicken in the district of Arua, Uganda, in 2011. This is the first documented isolation of a rhabdovirus from a chicken. SUNV is related to, but distinct from, Boteke virus and other members of the unclassified Sandjimba group. The genome is 11056 nt in length and contains the five core rhabdovirus genes plus an additional C gene (within the ORF of a phosphoprotein gene) and a small hydrophobic protein (between the matrix and glycoprotein genes). Inoculation of vertebrate cells with SUNV resulted in significant viral growth, with a peak titre of 7.8 log10 p.f.u. ml(-1) observed in baby hamster kidney (BHK) cells. Little to no growth was observed in invertebrate cells and in live mosquitoes, with Anopheles gambiae mosquitoes having a 47.4% infection rate in the body but no dissemination of the virus to the salivary glands; this suggests that this novel virus is not arthropod borne as some other members of the family Rhabdoviridae.

[PubMed - indexed for MEDLINE]
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