Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nanoscale Res Lett. 2014 Apr 4;9(1):161. doi: 10.1186/1556-276X-9-161.

Grafting of bovine serum albumin proteins on plasma-modified polymers for potential application in tissue engineering.

Author information

  • 1Department of Solid State Engineering, Institute of Chemical Technology Prague, Technicka 5, Prague 166 28, Czech Republic. nikola.kasalkova@vscht.cz.

Abstract

In this work, an influence of bovine serum albumin proteins grafting on the surface properties of plasma-treated polyethylene and poly-l-lactic acid was studied. The interaction of the vascular smooth muscle cells with the modified polymer surface was determined. The surface properties were characterized by X-ray photoelectron spectroscopy, atomic force microscopy, nano-LC-ESI-Q-TOF mass spectrometry, electrokinetic analysis, and goniometry. One of the motivations for this work is the idea that by the interaction of the cell with substrate surface, the proteins will form an interlayer between the cell and the substrate. It was proven that when interacting with the plasma-treated high-density polyethylene and poly-l-lactic acid, the bovine serum albumin protein is grafted on the polymer surface. Since the proteins are bonded to the substrate surface, they can stimulate cell adhesion and proliferation.

PMID:
24708858
[PubMed]
PMCID:
PMC3986457
Free PMC Article

Images from this publication.See all images (5)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk