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J Plast Reconstr Aesthet Surg. 2014 Jun;67(6):e162-4. doi: 10.1016/j.bjps.2014.03.014. Epub 2014 Mar 21.

Surgery results in complete cure of Lambert-Eaton myasthenic syndrome in a patient with metastatic Merkel cell carcinoma.

Author information

  • 1Welsh Centre for Burns and Plastic Surgery, Morriston Hospital, Swansea SA1 6NL, United Kingdom. Electronic address: richardsiau@doctors.org.uk.
  • 2Welsh Centre for Burns and Plastic Surgery, Morriston Hospital, Swansea SA1 6NL, United Kingdom; University Hospital of Wales, Heath Park, Cardiff CF14 4XW, United Kingdom.
  • 3Welsh Centre for Burns and Plastic Surgery, Morriston Hospital, Swansea SA1 6NL, United Kingdom.

Abstract

Lambert-Eaton myasthenic syndrome is a paraneoplastic phenomenon associated with neuroendocrine tumours, most frequently small cell lung carcinoma. Merkel cell carcinoma is a rare cause of Lambert-Eaton myasthenic syndrome. A 70-year old gentleman was referred with metastatic axillary nodal disease from a previously resected Merkel cell carcinoma of the left arm. Pre-operatively, the patient was wheelchair-bound from Lambert-Eaton myasthenic syndrome. Level I-III left axillary node clearance was performed and within 6 months, he had experienced full recovery of muscle power and mobility. We describe a case of complete cure of Lambert-Eaton myasthenic syndrome following axillary nodal clearance in a patient with metastatic Merkel cell carcinoma.

Copyright © 2014 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

KEYWORDS:

LEMS; Lambert–Eaton myasthenic syndrome; Merkel cell carcinoma; Neurology; Paraneoplastic; Surgery

PMID:
24704152
[PubMed - indexed for MEDLINE]
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