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Cell Stem Cell. 2014 Apr 3;14(4):423-4. doi: 10.1016/j.stem.2014.03.011.

Tailor made protein synthesis for HSCs.

Author information

  • 1Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA. Electronic address: mbarna@stanford.edu.
  • 2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: davide.ruggero@ucsf.edu.

Abstract

Translation control is a prevalent form of gene expression regulation in developmental and stem cell biology. A recent paper by Signer et al. (2014) measures protein synthesis in the mouse hematopoietic compartment and reveals the importance of diminished protein production for maintaining hematopoietic stem cell function and restraining oncogenic potential.

Copyright © 2014 Elsevier Inc. All rights reserved.

PMID:
24702992
[PubMed - indexed for MEDLINE]
PMCID:
PMC4071939
[Available on 2015-04-03]
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