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Nature. 1989 May 4;339(6219):27-30.

The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells.

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  • Cancer Research Unit, Walter and Eliza Hall Institute, Royal Melbourne Hospital, Victoria, Australia.


Several glycoproteins that control blood-cell production and function have been purified and sequenced. The four colony-stimulating factors interact in a complex way to regulate the differentiation and maturation of the granulocyte and macrophage lineages and have potential applications for the clinical manipulation of blood-cell production.

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