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Dev Cell. 2014 Mar 31;28(6):604-6. doi: 10.1016/j.devcel.2014.03.010.

Caspase-3, shears for synapse pruning.

Author information

  • 1Department of Neuroscience and Regenerative Medicine and Department of Neurology, Medical College of Georgia, Georgia Regents University, 1120 15(th) Street, Augusta, GA 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA 30904, USA.
  • 2Department of Neuroscience and Regenerative Medicine and Department of Neurology, Medical College of Georgia, Georgia Regents University, 1120 15(th) Street, Augusta, GA 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA 30904, USA. Electronic address: lmei@gru.edu.

Abstract

Motor neurons regulate neuromuscular junction formation by using agrin to stimulate acetylcholine receptor clustering and using acetylcholine to disperse unnecessary receptor clusters on muscle fibers. Wang et al. (2014) now report in this issue of Developmental Cell a critical role for caspase-3 in intracellular mechanisms of acetylcholine-induced dispersal.

Copyright © 2014 Elsevier Inc. All rights reserved.

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PMID:
24697895
[PubMed - indexed for MEDLINE]
PMCID:
PMC4176701
[Available on 2015/3/31]
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