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Int J Clin Exp Pathol. 2014 Feb 15;7(3):848-57. eCollection 2014.

Advances in serous tubal intraepithelial carcinoma: correlation with high grade serous carcinoma and ovarian carcinogenesis.

Author information

  • 1Department of Pathology, The First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, P. R. China ; Department of Pathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
  • 2Department of Pathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA ; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing, P. R. China.
  • 3Department of Obstetric and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing, P. R. China.
  • 4Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, P. R. China.
  • 5Department of Pathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
  • 6Department of Pathology, Forth Military Medical University Xi'an, Shanaxi, P. R. China.
  • 7Department of Pathology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
  • 8Department of Pathology, The First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, P. R. China.

Abstract

Early serous carcinoma in fallopian tube or serous tubal intraepithelial carcinoma (STIC), an early lesion limited to the epithelium of the fallopian tube and firstly identified from specimen obtained by prophylactic salpingo-oophorectomy, has provided insight into pelvic high grade serous carcinoma (HGSC). Increasing evidence indicates that STIC is a likely precursor for HGSC and several studies have focused on this lesion and its clinical significance. This review addresses recent advances in recognizing STIC and its correlation with HGSC and ovarian carcinogenesis. It also describes evidence regarding the fallopian tube as a source of some HGSCs, the protocol for optimizing histological evaluation of the tubes, the spectrum of tubal lesions from benign to noninvasive carcinoma, changes in diagnostic criteria from purely morphologic characteristics to a combination of morphologic features and molecular biomarkers, and new studies about potential biomarkers. However, the direct evidence regarding STIC as the precursor of HGSC is still tantalizing due to other possibilities that may also explain the origin of pelvic HGSC. Further molecular genetic studies are required to address this important question.

KEYWORDS:

Serous tubal intraepithelial carcinoma; carcinogenesis; fallopian tube; high grade serous carcinoma; ovarian cancer

PMID:
24696706
[PubMed - indexed for MEDLINE]
PMCID:
PMC3971287
Free PMC Article
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