Format

Send to:

Choose Destination
See comment in PubMed Commons below
Oxid Med Cell Longev. 2014;2014:641979. doi: 10.1155/2014/641979. Epub 2014 Feb 18.

Dysregulation of histone acetyltransferases and deacetylases in cardiovascular diseases.

Author information

  • 1Cardiovascular Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China ; Department of Pediatrics, Kosair Children Hospital Research Institute, University of Louisville, 570 South Preston Street, Baxter I, Suite 304F, Louisville, KY 40202, USA.
  • 2Department of Pediatrics, Kosair Children Hospital Research Institute, University of Louisville, 570 South Preston Street, Baxter I, Suite 304F, Louisville, KY 40202, USA ; The Second Hospital of Jilin University, Changchun 130041, China.
  • 3Department of Pediatrics, Kosair Children Hospital Research Institute, University of Louisville, 570 South Preston Street, Baxter I, Suite 304F, Louisville, KY 40202, USA.
  • 4Department of Pediatrics, Kosair Children Hospital Research Institute, University of Louisville, 570 South Preston Street, Baxter I, Suite 304F, Louisville, KY 40202, USA ; The Second Artillery General Hospital, Beijing 100088, China.
  • 5Cardiovascular Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.

Abstract

Cardiovascular disease (CVD) remains a leading cause of mortality worldwide despite advances in its prevention and management. A comprehensive understanding of factors which contribute to CVD is required in order to develop more effective treatment options. Dysregulation of epigenetic posttranscriptional modifications of histones in chromatin is thought to be associated with the pathology of many disease models, including CVD. Histone acetyltransferases (HATs) and deacetylases (HDACs) are regulators of histone lysine acetylation. Recent studies have implicated a fundamental role of reversible protein acetylation in the regulation of CVDs such as hypertension, pulmonary hypertension, diabetic cardiomyopathy, coronary artery disease, arrhythmia, and heart failure. This reversible acetylation is governed by enzymes that HATs add or HDACs remove acetyl groups respectively. New evidence has revealed that histone acetylation regulators blunt cardiovascular and related disease states in certain cellular processes including myocyte hypertrophy, apoptosis, fibrosis, oxidative stress, and inflammation. The accumulating evidence of the detrimental role of histone acetylation in cardiac disease combined with the cardioprotective role of histone acetylation regulators suggests that the use of histone acetylation regulators may serve as a novel approach to treating the millions of patients afflicted by cardiac diseases worldwide.

PMID:
24693336
[PubMed - indexed for MEDLINE]
PMCID:
PMC3945289
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Write to the Help Desk