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Head Neck. 2014 Apr 2. doi: 10.1002/hed.23700. [Epub ahead of print]

MicroRNA-155 in oral squamous cell carcinoma: Overexpression, localization, and prognostic potential.

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  • 1Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Abstract

BACKGROUND:

Oral squamous cell carcinoma (OSCC) is a common malignancy with poor prognosis. MicroRNAs (miRNAs) play an important role in cancer, but their role in OSCC is not clarified.

METHODS:

We performed miRNA microarray, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and fluorescence in situ hybridization (FISH) to examine miRNA expression in OSCC and paired adjacent cancer-free mucosal (ACF) tissues.

RESULTS:

Thirteen miRNAs, including miRNA-155, were upregulated (>2-fold) in OSCC against ACF. MiRNA-155 was confirmed to have significantly higher expression in OSCC against ACF (paired-samples t test; p = .041) and it was localized in the cancer nest, inflammatory area, and vascular endothelium of OSCC. High expression of miRNA-155 in ACF tissue was an independent prognostic indicator for OSCC survival.

CONCLUSION:

MiRNA-155 was overexpressed in OSCC and it was located in the cancer nest, inflammatory area, and vascular endothelium of OSCC. High miRNA-155 expression level in ACF may predict poor prognosis in patients with OSCC. © 2014 Wiley Periodicals, Inc. Head Neck, 2014.

Copyright © 2014 Wiley Periodicals, Inc.

KEYWORDS:

fluorescence in situ hybridization; microRNA-155; oral squamous cell carcinoma; polymerase chain reaction (PCR); prognosis

PMID:
24692283
[PubMed - as supplied by publisher]
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