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Cold Spring Harb Perspect Med. 2014 Apr 1;4(4):a014373. doi: 10.1101/cshperspect.a014373.

c-MYC-induced genomic instability.

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  • 1Manitoba Institute of Cell Biology, University of Manitoba, CancerCare Manitoba, Winnipeg, Manitoba R3E 0V9, Canada.

Abstract

MYC dysregulation initiates a dynamic process of genomic instability that is linked to tumor initiation. Early studies using MYC-carrying retroviruses showed that these viruses were potent transforming agents. Cell culture models followed that addressed the role of MYC in transformation. With the advent of MYC transgenic mice, it became obvious that MYC deregulation alone was sufficient to initiate B-cell neoplasia in mice. More than 70% of all tumors have some form of c-MYC gene dysregulation, which affects gene regulation, microRNA expression profiles, large genomic amplifications, and the overall organization of the nucleus. These changes set the stage for the dynamic genomic rearrangements that are associated with cellular transformation.

PMID:
24692190
[PubMed - indexed for MEDLINE]
PMCID:
PMC3968784
Free PMC Article
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