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J Infect Dis. 2014 Oct 1;210(7):1042-6. doi: 10.1093/infdis/jiu206. Epub 2014 Mar 31.

Tumor necrosis factor α is associated with viral control and early disease progression in patients with HIV type 1 infection.

Author information

  • 1Ragon Institute of MGH, MIT, and Harvard, Cambridge Division of Infectious Diseases, Massachusetts General Hospital.
  • 2Ragon Institute of MGH, MIT, and Harvard, Cambridge.
  • 3Division of Infectious Diseases, Massachusetts General Hospital.
  • 4Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts;
  • 5Ragon Institute of MGH, MIT, and Harvard, Cambridge Department of Viral Immunology, Heinrich-Pette-Institut, Hamburg, Germany.

Abstract

Inflammation in early human immunodeficiency virus type 1 (HIV-1) disease progression is not well characterized. Ninety patients with untreated primary HIV-1 infection were studied to determine associations of inflammatory proteins with early disease progression. High plasma tumor necrosis factor α (TNF-α) levels (≥8.5 pg/mL) were significantly associated with an increased viral load set point and shorter times to reaching a CD4(+) T-cell count of <500 cells/mm(3) and initiating antiretroviral therapy. The increased risk of reaching a CD4(+) T-cell count of <500 cells/mm(3) in the group with high TNF-α levels was driven by viral load but was independent of concurrent CD4(+) T-cell count. Thus, TNF-α appears to be an important mediator of inflammation in patients with poor viral control and early HIV-1 disease progression.

© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

KEYWORDS:

HIV/AIDS; TNF-α; disease progression; inflammation; viral load set point

PMID:
24688071
[PubMed - indexed for MEDLINE]
PMCID:
PMC4215080
[Available on 2015-10-01]
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