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Bioorg Med Chem Lett. 2014 May 1;24(9):2137-40. doi: 10.1016/j.bmcl.2014.03.036. Epub 2014 Mar 22.

The discovery and SAR of cyclopenta[b]furans as inhibitors of CCR2.

Author information

  • 1Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA. Electronic address: mwinter4@its.jnj.com.
  • 2Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA.

Abstract

The discovery of a novel series of cyclopenta[b]furans as CCR2 inhibitors is discussed. This series has excellent CCR2 potency and PK characteristics, and good cardiovascular safety.

Copyright © 2014 Elsevier Ltd. All rights reserved.

KEYWORDS:

CCR2; Cyclopenta[b]furan; MCP-1; Thioglycolate-induced peritoneal leukocyte infiltration model; Type II diabetes

PMID:
24685539
[PubMed - in process]
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