Format

Send to:

Choose Destination
See comment in PubMed Commons below
Fitoterapia. 2014 Jun;95:258-65. doi: 10.1016/j.fitote.2014.03.014. Epub 2014 Mar 29.

Anti-ulcer xanthones from the roots of Hypericum oblongifolium Wall.

Author information

  • 1Department of Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan. Electronic address: mumtazphd@gmail.com.
  • 2Department of Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan. Electronic address: dralatif@uom.edu.pk.
  • 3Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan.
  • 4Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan.
  • 5Chemical and Forensic Sciences, University of Bradford, BD7 1DP, UK.
  • 6Department of Genetics, Hazara University, Mansehra, Pakistan.
  • 7Department of Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan.

Abstract

Three new xanthones, hypericorin C (1), hypericorin D (2) and 3,4-dihydroxy-5-methoxyxanthone (3), along with eight known compounds; 2,3-dimethoxyxanthone (4), 3,4-dihydroxy-2-methoxyxanthone (5), 3,5-dihydroxy-1-methoxyxanthone (6), 3-acetylbetulinic acid (7), 10H-1,3-dioxolo[4,5-b]xanthen-10-one (8), 3-hydroxy-2-methoxyxanthone (9), 3,4,5-trihydroxyxanthone (10) and betulinic acid (11) were isolated from the roots of Hypericum oblongifolium. The structures of the new compounds 1, 2 and 3 were deduced by spectroscopic techniques [ESI MS, (1)H NMR, (13)C NMR, and 2D NMR (HMQC, HMBC, COSY and NOESY)]. The entire series of compounds were evaluated for anti-ulcer activity.

Copyright © 2014 Elsevier B.V. All rights reserved.

KEYWORDS:

2D-NMR; Anti-ulcer; Hypericorin C; Hypericorin D; Hypericum oblongifolium Wall; Xanthones

PMID:
24685505
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk