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Clin Immunol. 2014 May-Jun;152(1-2):36-47. doi: 10.1016/j.clim.2014.01.009. Epub 2014 Feb 13.

Secretion of interleukin-17 by CD8+ T cells expressing CD146 (MCAM).

Author information

  • 1Hematology Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.
  • 2Center for Human Immunology, Autoimmunity and Inflammation, NIH, Bethesda, MD 20892, USA.
  • 3Clinical Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • 4Center for Human Immunology, Autoimmunity and Inflammation, NIH, Bethesda, MD 20892, USA; Clinical Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • 5Hematology Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA; Center for Human Immunology, Autoimmunity and Inflammation, NIH, Bethesda, MD 20892, USA. Electronic address: mccoyjp@mail.nih.gov.

Abstract

Interleukin-17 (IL-17) has been associated with the pathogenesis of numerous autoimmune diseases. CD4+ T cells secreting IL-17 are termed Th17 cells. CD8+ T cells, designated Tc17 cells, are also capable of secreting IL-17. Here we describe a population of Tc17 cells characterized by the expression of surface CD146, an endothelial adhesion molecule. These cells display signatures of a human Tc17 genotype and phenotype. Circulating CD8+CD146+ T cells are present in low levels in healthy adults. Elevations in CD8+CD146+ T cells are found in Behcet's disease and birdshot retinochoroidopathy, which have been reported to have HLA class I associations. Sarcoidosis does not have a class I association and displays an increase in CD4+ CD146+ T cells but not in CD8+CD146+ T cells. CD146 on these cells may facilitate their ability to bind to, and migrate through, endothelium, as has been reported for CD4+CD146+ T cells.

Published by Elsevier Inc.

KEYWORDS:

CD146/MCAM; Class I antigen; Inflammation; Tc17

PMID:
24681356
[PubMed - indexed for MEDLINE]
PMCID:
PMC4004661
[Available on 2015/5/1]
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