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Endocrinol Nutr. 2014 Aug-Sep;61(7):351-8. doi: 10.1016/j.endonu.2014.01.010. Epub 2014 Mar 26.

Prevalence of hyperandrogenism and polycystic ovary syndrome in female to male transsexuals.

[Article in English, Spanish]

Author information

  • 1Unidad de Identidad de Género, Servicio de Endocrinología, Hospital Universitario Ramón y Cajal, Madrid, España; Departamento de Ciencias Biomédicas, Universidad de Alcalá, Alcalá de Henares, Madrid, España. Electronic address: a.becerrafernandez@gmail.com.
  • 2Servicio de Endocrinología, Hospital Comarcal de Melilla, Melilla, España.
  • 3Servicio de Bioquímica Clínica, Hospital Universitario Ramón y Cajal, Madrid, España.
  • 4Unidad de Identidad de Género, Servicio de Endocrinología, Hospital Universitario Ramón y Cajal, Madrid, España.
  • 5Departamento de Ciencias Biomédicas, Universidad de Alcalá, Alcalá de Henares, Madrid, España.

Abstract

INTRODUCTION:

Prevalence of hyperandrogenism (HA), including the polycystic ovary syndrome (PCOS), in female-to-male transsexuals (FMT) is high. This has been related to metabolic syndrome (MS), which appears to increase cardiovascular morbidity and mortality throughout cross-sex hormone (CSH) therapy.

OBJECTIVES:

To assess the prevalence of HA and PCOS in FMT patients before the start of CSH therapy, and their association to MS and its components, insulin resistance (IR) and other cardiovascular risk (CVR) factors.

MATERIALS AND METHODS:

Seventy-seven FMTs underwent clinical and biochemical assessment for HA before the start of CSH therapy. CVR, IR, and other MS parameters were also assessed.

RESULTS:

Prevalence of HA was 49.4% (73.7% were cases of PCOS [Rotterdam criteria]), and prevalence of PCOS in the overall sample was 36.4%. Prevalence of MS was 38.4% and 51.7% according to ATP-III and IDF criteria respectively). MS (according to ATP-III and IDF criteria respectively) was found in 36.8% and 57.9% as compared to 25.6% and 41% of patients with and without HA respectively (p<0.0001 and P<0.01 respectively). Of total patients, 54.5% had normal weight (body mass index [BMI] 18.5-24.9 kg.m(-2)), 26% were overweight (BMI 25-29.9 kg.m(-2)), and 19.5% were obese (BMI ≥ 30 kg.m(-2)). After adjusting for BMI, the comparison of hormonal, metabolic, and anthropometric parameters showed statistically significant differences in plasma glucose, HOMA-IR, and abdominal circumference (P<0.001 for all), as well as HDL cholesterol (HDL) (P=0.033), but not in total testosterone or calculated free testosterone levels. In the total sample, 27.3% had HDL levels less than 50mg/dL.

CONCLUSIONS:

Overall HA, and PCOS in particular, are highly prevalent in FMTs. HA and PCOS are related to early development of SM, IR, and other CVR factors with unknown consequences in adulthood.

Copyright © 2013 SEEN. Published by Elsevier Espana. All rights reserved.

KEYWORDS:

Female-to-male transsexuals; Hiperandrogenismo; Hyperandrogenism; Metabolic syndrome; Polycystic ovary syndrome; Prevalence; Prevalencia; Síndrome de ovario poliquístico; Síndrome metabólico; Transexuales de mujer a hombre

PMID:
24680383
[PubMed - in process]
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