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J Neurol Sci. 2014 May 15;340(1-2):144-9. doi: 10.1016/j.jns.2014.03.014. Epub 2014 Mar 14.

Determinants of the quality of life in Parkinson's disease: results of a cohort study from Southwest China.

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  • 1Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China.
  • 2Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China. Electronic address:



The determinants of the quality of life (QoL) of patients with Parkinson's disease (PD) in Chinese population remain largely unknown.


A total of 649 PD patients from Southwest China participated in this cross-sectional study. Non-motor Symptoms Scale (NMSS) was used to evaluate the non-motor symptoms (NMS), whereas PD Quality of Life Questionnaire (PDQ-39) was used to assess the QoL of the PD patients. Multiple stepwise regression analysis was conducted to identify the determinants of the QoL.


NMS, H-Y stage, female, disease duration, UPDRS III score, single/divorced/widowed, and motor complications accounted for 66.3% of the variables in the multiple regression analysis and were the negative determinants of the QoL. Among these variables, NMS and H-Y stage accounted for 46.7% and 14.5%, respectively. NMS were closely associated with each domain of PDQ-39. Female sex especially predicted poor emotional well-being and bodily discomfort, whereas single/divorced/widowed especially predicted poor stigma and social support of PD patients. Comorbidity, motor complications and rural living predicted poor mobility, activities of daily living and emotional well-being, respectively.


Both demographic and disease-specific factors influence the QoL in PD patients. NMS are the strongest independent negative determinant of the overall QoL and closely associated with each domain of PDQ-39. The treatment of NMS may help to improve the QoL of PD patients.

Copyright © 2014 Elsevier B.V. All rights reserved.


Determinants; Motor severity; Non-motor symptoms (NMS); PDQ-39; Parkinson disease; Quality of life (QoL)

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