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Bioorg Med Chem Lett. 2014 Apr 15;24(8):1895-900. doi: 10.1016/j.bmcl.2014.03.014. Epub 2014 Mar 15.

Anti-inflammatory components of Euphorbia humifusa Willd.

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  • 1College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
  • 2College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 3Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Wonkwang Oriental Medicines Research Institute, Iksan, Jeonbuk 570-749, Republic of Korea.
  • 4Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Wonkwang Oriental Medicines Research Institute, Iksan, Jeonbuk 570-749, Republic of Korea. Electronic address: ymlee@wku.ac.kr.
  • 5College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea. Electronic address: yhk@cnu.ac.kr.

Abstract

Two new compounds, euphorbinoside (1) and dehydropicrorhiza acid methyl diester (2), along with 24 known compounds (3-26) were isolated from Euphorbia humifusa Willd. The effects of these compounds on soluble epoxide hydrolase (sEH) inhibitory activity were evaluated. Flavonoid compounds (10-21) exhibited high sEH inhibitory activity. Among them, compounds 12, 13, and 19 greatly inhibited sEH enzymatic activity, with IC50 values as low as 18.05±1.17, 18.64±1.83, and 17.23±0.84 μM, respectively. In addition, the effects of these compounds on lipopolysaccharide (LPS)-induced nitric oxide (NO) and tumor necrosis factor alpha (TNF-α) production by RAW 264.7 cells were investigated. Compounds 3-6, 8, 18, 20-23, and 25-26 inhibited the production of both NO and TNF-α, with IC50 values ranging from 11.1±0.9 to 45.3±1.6 μM and 14.4±0.5 to 44.5±1.2 μM, respectively.

Copyright © 2014 Elsevier Ltd. All rights reserved.

KEYWORDS:

Dehydropicrorhiza acid methyl diester; Euphorbia humifusa; Euphorbinoside; NO; Soluble epoxide hydrolase; TNF-α

PMID:
24679441
[PubMed - indexed for MEDLINE]

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