Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD

Cleo L Crunelle; Wim van den Brink; Geert Dom; Jan Booij

doi:10.1192/bjp.bp.113.132977

Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD

Br J Psychiatry. 2014 Jun;204(6):486-7. doi: 10.1192/bjp.bp.113.132977. Epub 2014 Mar 27.

Authors

Cleo L Crunelle¹, Wim van den Brink¹, Geert Dom¹, Jan Booij¹

Affiliation

¹ Cleo L. Crunelle, PhD, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Belgium; Amsterdam Institute for Addiction Research and Departments of Psychiatry and Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands; Wim van den Brink, MD, PhD, Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands; Geert Dom, MD, PhD, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, and Psychiatric Centre Alexian Brothers, Boechout, Belgium; Jan Booij, MD, PhD, Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.

PMID: 24676965
DOI: 10.1192/bjp.bp.113.132977

Abstract

Impulsivity is a multidimensional construct, including impulsive decision-making and impulsive action, representing relatively independent neurocircuitries. ADHD is treated with methylphenidate, a drug that binds to dopamine transporters. This study in 24 adult male patients with ADHD shows that dopamine transporter occupancy by methylphenidate in the putamen correlates with improvements in cognitive but not in motor impulsivity.

Royal College of Psychiatrists.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Attention Deficit Disorder with Hyperactivity / drug therapy*
Dopamine Plasma Membrane Transport Proteins / drug effects*
Dopamine Uptake Inhibitors / therapeutic use
Humans
Impulsive Behavior / drug effects*
Male
Methylphenidate / therapeutic use*
Treatment Outcome

Substances

Dopamine Plasma Membrane Transport Proteins
Dopamine Uptake Inhibitors
Methylphenidate