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The gene that encodes the human CD20 (B1) differentiation antigen is located on chromosome 11 near the t(11;14)(q13;q32) translocation site.
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA 02115.
The human CD20 gene (B1) encodes a B lymphocyte-specific, cell-surface molecule that is involved in B cell activation and differentiation. We report that the CD20 gene is located on human chromosome 11 at position q12-q13. The location of CD20 was determined by in situ hybridization and was further confirmed by Southern blot analysis of DNA from rodent/human hybrids that contained only portions of human chromosome 11. This localization places the CD20 gene near the site of the t(11;14)(q13;q32) translocation that is found in a subgroup of B cell-lineage malignancies. The site of this translocation has been previously identified by DNA cloning and termed bcl-1. The CD20 gene was found to lie on the centromeric side of bcl-1 on chromosome 11 and to be separated from bcl-1 by at least 50 kb of DNA. These results raise the possibility that alterations in the expression of the CD20 gene may result after the t(11;14) chromosomal alteration.
PMID: 2466898 [PubMed - indexed for MEDLINE]
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Cited by 4 PubMed Central articles
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Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes.
Bubien JK, Zhou LJ, Bell PD, Frizzell RA, Tedder TF.
J Cell Biol. 1993 Jun; 121(5):1121-32.
[J Cell Biol. 1993]
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A frequent human CD20 (B1) differentiation antigen DNA polymorphism detected with MspI is located near 11q12-13.
Charmley P, Nguyen J, Tedder TF, Gatti RA.
Nucleic Acids Res. 1990 Jan 11; 18(1):207.
[Nucleic Acids Res. 1990]
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A radiation hybrid map of the proximal long arm of human chromosome 11 containing the multiple endocrine neoplasia type 1 (MEN-1) and bcl-1 disease loci.
Richard CW 3rd, Withers DA, Meeker TC, Maurer S, Evans GA, Myers RM, Cox DR.
Am J Hum Genet. 1991 Dec; 49(6):1189-96.
[Am J Hum Genet. 1991]
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