Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Hematol. 2014 Jul;89(7):695-7. doi: 10.1002/ajh.23720. Epub 2014 Apr 15.

Successful treatment of intravenously abused oral Opana ER-induced thrombotic microangiopathy without plasma exchange.

Author information

  • 1Department of Medicine, Section on Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Abstract

In January 2013, the Centers for Disease Control and Prevention reported an illness associated with intravenous (IV) abuse of oral Opana ER (oxymorphone) in Tennessee. The clinical presentation of this syndrome was reported to resemble that of thrombotic thrombocytopenic purpura in the 15 patients reported; 12 were treated with plasma exchange. We report a similar case series of 15 patients with 18 episodes of thrombotic microangiopathy associated with recent IV abuse of oral Opana ER. In our series, we demonstrate that therapeutic plasma exchange is unnecessary; supportive care and treatment of underlying infections and renal dysfunction (without use of plasma exchange) resulted in clinical improvement in all patients. Thus, it appears that plasma exchange with associated costs and risks can be safely omitted in patients with thrombotic microangiopathy resulting from IV abuse of oral Opana ER.

© 2014 Wiley Periodicals, Inc.

PMID:
24668845
[PubMed - in process]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk