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Eur Rev Med Pharmacol Sci. 2014;18(5):740-52.

Characterization of an injectable chitosan-demineralized bone matrix hybrid for healing critical-size long-bone defects in a rabbit model.

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  • 1Department of Orthopedics, Institute of Orthopedics, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China. houshuxun_2000@163.com.

Abstract

BACKGROUND:

The effect of injectable demineralized bone matrix (DBM) on bone repair is not known. Here, we tested the hypothesis that injectable DBM can heal a critical-size diaphyseal radius defect in a rabbit model.

MATERIALS AND METHODS:

The bone defect was filled with DBM powder, injectable DBM or powdered, freeze-dried powdered allografts. Radiological determination, gross evaluation, histology, and micro-computer tomography was carried out 4, 8, and 12 weeks after the surgery, respectively.

RESULTS:

The injectable DBM group yielded better when compared with the freeze-dried powder group (p < 0.05). Moreover, biomechanical functionality was restored comparable to normal levels in the injectable DBM group.

CONCLUSIONS:

The injectable DBM was as effective in structurally and functionally repairing bone defects as the DBM powder and more effective than the freeze-dried bone powder. Thus, our study supports the use of injectable DBM for bone healing.

PMID:
24668718
[PubMed - indexed for MEDLINE]
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