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Arch Med Res. 2014 Apr;45(3):251-6. doi: 10.1016/j.arcmed.2014.03.004. Epub 2014 Mar 20.

Serum ferritin concentration predicts mortality in patients with hepatitis B virus-related acute on chronic liver failure.

Author information

  • 1Department of Clinical Laboratory, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
  • 2Department of Colorectal Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
  • 3Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
  • 4Department of Emergency, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China. Electronic address: zjwdq0@163.com.

Abstract

BACKGROUND AND AIMS:

This study was designed to investigate the association between serum ferritin concentration (SF) and hepatitis B virus infected patients with acute-on-chronic liver failure (AoCLF). In addition, we analyzed whether SF levels are associated with mortality in AoCLF patients.

METHODS:

One hundred and seventeen patients, including 46 patients with chronic hepatitis B (CHB), 71 with AoCLF, and 55 healthy controls (HCs) were enrolled in this study. All patients were followed for 4 months. In all subjects, a blood sample was collected at admission to examine liver function, renal function, international normalized ratio, and SF levels. A total of six clinical chemistry and biochemical variables (e.g., model for end-stage liver disease [MELD] score, age, levels of SF, total protein, albumin, and alanine aminotransferase) were measured and analyzed for their association with outcomes by using Cox proportional hazards and multiple regression models.

RESULTS:

AoCLF patients had significantly higher SF levels at admission compared to HCs and CHB (all p = 0.001). Elevated SF levels were associated with increased severity of liver disease and 3-month mortality rate. Multivariate analysis demonstrated that SF levels and MELD score were independent predictors for mortality (both p <0.001).

CONCLUSION:

The SF measured at admission may serve as an independent predictor for 3-month mortality rate in AoCLF patients.

Copyright © 2014 IMSS. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

Acute-on-chronic liver failure (AoCLF); Serum ferritin concentration (SF); mortality

PMID:
24656903
[PubMed - indexed for MEDLINE]
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