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Oncoimmunology. 2014 Jan 1;3(1):e27219.

Early predictive value of multifunctional skin-infiltrating lymphocytes in anticancer immunotherapy.

Author information

  • 1Department of Tumor Immunology; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands.
  • 2Department of Medical Oncology; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands.
  • 3Department of Laboratory Medicine; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands.
  • 4Department of Medical Oncology; Academic Medical Center; University of Amsterdam; Amsterdam, The Netherlands.
  • 5Department of Tumor Immunology; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands ; Department of Medical Oncology; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands.

Abstract

Bioassays that predict clinical outcome are essential to optimize cellular anticancer immunotherapy. We have recently developed a robust and simple skin test to evaluate the capacity of tumor-specific T cells to migrate, recognize their targets and exert effector functions. This bioassay detects T cells with an elevated antineoplastic potential and hence rapidly identifies patients responding to immunotherapy.

KEYWORDS:

DC-based vaccination; biomarker; delayed-type hypersensitivity; immunomonitoring; melanoma; multifunctional T cells; skin-infiltrating lymphocytes

PMID:
24653961
[PubMed]
PMCID:
PMC3960298
Free PMC Article
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