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Cancer Cell. 2014 Mar 17;25(3):318-34. doi: 10.1016/j.ccr.2014.02.018.

From fly wings to targeted cancer therapies: a centennial for notch signaling.

Author information

  • 1Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, NY 10016, USA.
  • 2Departments of Pediatrics and Genetics, Stanford University, Stanford, CA 94305, USA.
  • 3Departments of Pediatrics and Genetics, Stanford University, Stanford, CA 94305, USA. Electronic address: julsage@stanford.edu.
  • 4Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, NY 10016, USA. Electronic address: iannis.aifantis@nyumc.org.

Abstract

Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago, Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a variety of organisms and tissues. However, in the past 20 years, accumulating evidence has linked alterations in the Notch pathway to tumorigenesis. In this review, we discuss the protumorigenic and tumor-suppressive functions of Notch signaling, and dissect the molecular mechanisms that underlie these functions in hematopoietic cancers and solid tumors. Finally, we link these mechanisms and observations to possible therapeutic strategies targeting the Notch pathway in human cancers.

Copyright © 2014 Elsevier Inc. All rights reserved.

PMID:
24651013
[PubMed - indexed for MEDLINE]
PMCID:
PMC4040351
[Available on 2015/3/17]
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