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Biomed Rep. 2013 Nov;1(6):833-836. Epub 2013 Sep 25.

Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review).

Author information

  • 1Department of Burns and Plastic Surgery, Digestive and Vascular Surgery Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
  • 2Department of Hydatid Hepatobiliary, Digestive and Vascular Surgery Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.

Abstract

It was previously demonstrated that the main cause behind keloid formation may be keloid fibroblast abnormalities, which are closely associated with the microenvironment of the keloid lesion. The post-traumatic and chronic inflammation of the keloid lesion area suggest that inflammatory mediators play an important role in the keloid microenvironment and are crucial for keloid fibroblast abnormalities. In this study, we hypothesized that the mechanism underlying keloid formation may involve the continuous upregulation of proinflammatory gene expression in keloid lesions. This hypothesis may explain the inflammatory response, invasive growth and recurrence following resection of keloids, as well as the selective localization of keloids in specific parts of a patient's body and the differences in localization among different patients.

KEYWORDS:

keloid formation; proinflammatory genes; skin lesion

PMID:
24649037
[PubMed]
PMCID:
PMC3917036
Free PMC Article
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