Mol Endocrinol. 1989 Jan;3(1):179-84.

Expression and regulation of the proenkephalin gene in rat Sertoli cells.

Source

Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545.

Abstract

Previous studies have shown that multiple forms of proenkephalin RNA are present in the rat and mouse testis that are cell type specific: a 1700-nucleotide transcript, unique to the testis, found in spermatogenic cells, and a 1450-nucleotide form of somatic cell origin. In the present studies, rat Sertoli cells are shown to contain the 1450-nucleotide form of proenkephalin RNA. The concentration of this transcript is quite low immediately after Sertoli cell isolation, but increases after 1 day in culture to a constant level. Proenkephalin RNA levels are stimulated severalfold by FSH and cAMP, but are not significantly affected by LH or testosterone. These studies demonstrate that Sertoli cells are at least one source of the somatic, 1450-nucleotide form of proenkephalin RNA in the rat testis. The expression of opioid peptide genes by Sertoli cells as well as by germ and Leydig cells is further evidence for the postulated autocrine or paracrine functions of these peptides in the testis.

PMID:: 2464755; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

HighWire Press

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Human chorionic gonadotropin regulates expression of the proenkephalin gene in adult rat Leydig cells. [Mol Endocrinol. 1989]
Human chorionic gonadotropin regulates expression of the proenkephalin gene in adult rat Leydig cells.
Garrett JE, Douglass JO. Mol Endocrinol. 1989 Dec; 3(12):2093-100.
A germ cell factor(s) modulates preproenkephalin gene expression in rat Sertoli cells. [Mol Cell Endocrinol. 1992]
A germ cell factor(s) modulates preproenkephalin gene expression in rat Sertoli cells.
Fujisawa M, Bardin CW, Morris PL. Mol Cell Endocrinol. 1992 Mar; 84(1-2):79-88.
Expression of the enkephalin precursor gene in rat Sertoli cells. Regulation by follicle-stimulating hormone. [FEBS Lett. 1988]
Expression of the enkephalin precursor gene in rat Sertoli cells. Regulation by follicle-stimulating hormone.
Yoshikawa K, Aizawa T. FEBS Lett. 1988 Sep 12; 237(1-2):183-6.
Glutathione S-transferase alpha expressed in porcine Sertoli cells is under the control of follicle-stimulating hormone and testosterone. [Biol Reprod. 2002]
Glutathione S-transferase alpha expressed in porcine Sertoli cells is under the control of follicle-stimulating hormone and testosterone.
Benbrahim-Tallaa L, Tabone E, Tosser-Klopp G, Hatey F, Benahmed M. Biol Reprod. 2002 Jun; 66(6):1734-42.
Review Paracrine regulation of testicular function. [J Steroid Biochem. 1987]
Review Paracrine regulation of testicular function.
Saez JM, Perrard-Sapori MH, Chatelain PG, Tabone E, Rivarola MA. J Steroid Biochem. 1987; 27(1-3):317-29.

See reviews... See all...

Cited by 5 PubMed Central articles

Review Regulation of male fertility by the opioid system. [Mol Med. 2011]
Review Regulation of male fertility by the opioid system.
Subirán N, Casis L, Irazusta J. Mol Med. 2011; 17(7-8):846-53. Epub 2011 Mar 16.
Expression of a novel, sterol-insensitive form of sterol regulatory element binding protein 2 (SREBP2) in male germ cells suggests important cell- and stage-specific functions for SREBP targets during spermatogenesis. [Mol Cell Biol. 2002]
Expression of a novel, sterol-insensitive form of sterol regulatory element binding protein 2 (SREBP2) in male germ cells suggests important cell- and stage-specific functions for SREBP targets during spermatogenesis.
Wang H, Liu F, Millette CF, Kilpatrick DL. Mol Cell Biol. 2002 Dec; 22(24):8478-90.
Transcription of the rat and mouse proenkephalin genes is initiated at distinct sites in spermatogenic and somatic cells. [Mol Cell Biol. 1990]
Transcription of the rat and mouse proenkephalin genes is initiated at distinct sites in spermatogenic and somatic cells.
Kilpatrick DL, Zinn SA, Fitzgerald M, Higuchi H, Sabol SL, Meyerhardt J. Mol Cell Biol. 1990 Jul; 10(7):3717-26.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Expression and regulation of the proenkephalin gene in rat Sertoli cells.
Expression and regulation of the proenkephalin gene in rat Sertoli cells.
Mol Endocrinol. 1989 Jan ;3(1):179-84.

PubMed
Effect of chronic D-fenfluramine administration on rat hypothalamic serotonin le...
Effect of chronic D-fenfluramine administration on rat hypothalamic serotonin levels and release.
Life Sci. 1989 ;44(4):265-71.

PubMed
Relation of protein synthesis and transglutaminase activity to formation of the ...
Relation of protein synthesis and transglutaminase activity to formation of the cross-linked envelope during terminal differentiation of the cultured human epidermal keratinocyte.
J Cell Biol. 1978 Mar ;76(3):705-11.

PubMed
Methods for staining amyloid in tissues: a review.
Methods for staining amyloid in tissues: a review.
Stain Technol. 1988 Jul ;63(4):201-12.

PubMed
Oral digestion of a complex-carbohydrate cereal: effects of stress and relaxatio...
Oral digestion of a complex-carbohydrate cereal: effects of stress and relaxation on physiological and salivary measures.
Am J Clin Nutr. 1989 Jan ;49(1):97-105.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Expression and regulation of the proenkephalin gene in rat Sertoli cells.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 5 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information