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Chem Commun (Camb). 2014 Apr 28;50(33):4347-50. doi: 10.1039/c4cc00320a.

Proteome reactivity profiling for the discrimination of pathogenic bacteria.

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  • 1Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seoul, 136-791, Korea.


Diverse proteome reactivity profiles were obtained using small-molecule electrophiles. Based on the cross-reactivity profile, each protein generated a unique reactivity fingerprint. Here, we report the first proteome reactivity signature-based discrimination of 11 bacteria. Perfect differentiation of 11 bacteria can be achieved using 2 benzyl-halide probes.

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