Send to:

Choose Destination
See comment in PubMed Commons below
Urology. 2014 May;83(5):1104-6. doi: 10.1016/j.urology.2014.01.008. Epub 2014 Mar 15.

Clinicopathologic features of renomedullary interstitial cell tumor presenting as the main solid renal mass.

Author information

  • 1Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY. Electronic address:
  • 2Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY.
  • 3Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.



To review the clinical, pathologic, and radiographic features of renomedullary interstitial cell tumor (RMICT). This is a rare benign renal tumor formerly known as medullary fibroma and is indistinguishable from other renal cortical tumors by imaging.


After institutional review board approval, we reviewed data on patients from the Memorial Sloan-Kettering Cancer Center kidney tumor database from 1989 to 2012 (4898 patients) with a pathologic diagnosis of RMICT or medullary fibroma as the main resected tumor. Data collected included procedure, age, gender, presentation, preoperative tumor characteristics (size, location, nearness to collecting system, and RENAL nephrometry score), and final pathologic size.


Ten patients (0.2%) with RMICT were identified. All patients had undergone partial nephrectomy for 10 tumors (9 right). Clinical presentation was incidental to abdominal imaging performed for another clinical reason in 6 patients, as part of a hematuria evaluation in 2 patients, and as part of nephrolithiasis follow-up imaging in 2 patients. The mean patient age was 52 years (range, 39-73), and 8 patients were female. The mean preoperative and final pathologic tumor size was 1.65 cm (range, 1.0-2.5) and 0.96 cm (range, 0.3-1.7), respectively. The location of the tumors was medullary (0-9 mm from the collecting system) in 8 patients and cortical (2.5 cm mostly exophytic and 1.5 cm mostly endophytic tumor) in 2 patients.


Our data demonstrate a female predominance, a mean tumor size of <2 cm, and medullary location consistent with its pathologic origin. To our knowledge, this is the largest single-institution series of RMICT.

Copyright © 2014 Elsevier Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk