Gene expression of androgen metabolising enzymes in benign prostatic hyperplasia

Klin Lab Diagn. 2013 Oct:(10):52-4, 16-8.
[Article in English, Russian]

Abstract

Benign prostatic hyperplasia is still one of the most important problems of modern urology. We studied the gene expression of androgen metabolic enzymes involved in the synthesis of androgens directly in the target organs in 20 patients using real-time RP-PCR. A significant increase in the mRNA of HSD1 7B3 approximately 1,7 fold, SRD5A2 approximately 2 fold, HSD3B1 approximately 2 fold, STS approximately 2,3 fold u AR -2.5 fold and reduced HSD17B2 approximately 4 fold in samples of tumor tissue compared with adjacent tissues.

MeSH terms

  • 17-Hydroxysteroid Dehydrogenases / genetics
  • 17-Hydroxysteroid Dehydrogenases / metabolism*
  • 3-Oxo-5-alpha-Steroid 4-Dehydrogenase / genetics
  • 3-Oxo-5-alpha-Steroid 4-Dehydrogenase / metabolism*
  • Aged
  • Aged, 80 and over
  • Androgens / metabolism
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Male
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Middle Aged
  • Multienzyme Complexes / genetics
  • Multienzyme Complexes / metabolism*
  • Progesterone Reductase / genetics
  • Progesterone Reductase / metabolism*
  • Prostatic Hyperplasia / enzymology*
  • Prostatic Hyperplasia / metabolism
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Steroid Isomerases / genetics
  • Steroid Isomerases / metabolism*
  • Steryl-Sulfatase / genetics
  • Steryl-Sulfatase / metabolism*
  • Transcription, Genetic

Substances

  • 3 beta-hydroxysteroid oxidoreductase-delta(5) 3-ketosteroid isomerase
  • Androgens
  • Membrane Proteins
  • Multienzyme Complexes
  • RNA, Messenger
  • 17-Hydroxysteroid Dehydrogenases
  • 17beta-hydroxysteroid dehydrogenase type 3
  • Progesterone Reductase
  • 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
  • SRD5A2 protein, human
  • STS protein, human
  • Steryl-Sulfatase
  • Steroid Isomerases