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Int J Epidemiol. 2015 Feb;44(1):37-48. doi: 10.1093/ije/dyu008. Epub 2014 Mar 16.

Cohort profile: project viva.

Author information

  • 1Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Channing Laboratory, Brigham and Women's Hospital, Boston, MA, USA, Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Boston, MA, USA, Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA, Department of Nutrition, Harvard School of Public Health, Boston, MA, USA, Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA, Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA, Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA, Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA, Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA, Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA, USA and Division of Neonatology, Boston Medical Center and Boston University School of Medicine, Boston, MA, USA emily_oken@hphc.org.
  • 2Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Channing Laboratory, Brigham and Women's Hospital, Boston, MA, USA, Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Boston, MA, USA, Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA, Department of Nutrition, Harvard School of Public Health, Boston, MA, USA, Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA, Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA, Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA, Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA, Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA, Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA, USA and Division of Neonatology, Boston Medical Center and Boston University School of Medicine, Boston, MA, USA Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Channing Laboratory, Brigham and Women's Hospital, Boston, MA, USA, Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Boston, MA, USA, Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA, Department of Nutrition, Harvard School of Public Health, Boston, MA, USA, Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA, Division of Newborn Medicine, B
  • 3Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Channing Laboratory, Brigham and Women's Hospital, Boston, MA, USA, Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Boston, MA, USA, Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA, Department of Nutrition, Harvard School of Public Health, Boston, MA, USA, Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA, Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA, Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA, Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA, Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA, Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA, USA and Division of Neonatology, Boston Medical Center and Boston University School of Medicine, Boston, MA, USA.

Abstract

We established Project Viva to examine prenatal diet and other factors in relation to maternal and child health. We recruited pregnant women at their initial prenatal visit in eastern Massachusetts between 1999 and 2002. Exclusion criteria included multiple gestation, inability to answer questions in English, gestational age ≥22 weeks at recruitment and plans to move away before delivery. We completed in-person visits with mothers during pregnancy in the late first (median 9.9 weeks of gestation) and second (median 27.9 weeks) trimesters. We saw mothers and children in the hospital during the delivery admission and during infancy (median age 6.3 months), early childhood (median 3.2 years) and mid-childhood (median 7.7 years). We collected information from mothers via interviews and questionnaires, performed anthropometric and neurodevelopmental assessments and collected biosamples. We have collected additional information from medical records and from mailed questionnaires sent annually to mothers between in-person visits and to children beginning at age 9 years. From 2341 eligible women, there were 2128 live births; 1279 mother-child pairs provided data at the mid-childhood visit. Primary study outcomes include pregnancy outcomes, maternal mental and cardiometabolic health and child neurodevelopment, asthma/atopy and obesity/cardiometabolic health. Investigators interested in learning more about how to obtain Project Viva data can contact Project_Viva@hphc.org.

© The Author 2014; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.

KEYWORDS:

Pregnancy; childhood; cohort; nutrition; obesity

PMID:
24639442
[PubMed - in process]
PMCID:
PMC4339753
[Available on 2016-02-01]
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