Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Muscle Nerve. 2014 Jul;50(1):114-8. doi: 10.1002/mus.24111. Epub 2014 May 5.

Prospective investigation of nimodipine for acute vocal fold paralysis.

Author information

  • 1University of Pittsburgh Voice Center, Department of Otolaryngology, University of Pittsburgh School of Medicine, UPMC Mercy Building B, Suite 11500, 1400 Locust Street, Pittsburgh, Pennsylvania, 15219, USA.

Abstract

INTRODUCTION:

Nimodipine has been shown to be beneficial for recovery from acute vocal fold paralysis (AVFP) in an animal model.

METHODS:

prospective, open-label trial of patients with AVFP was performed using nimodipine. Consecutive patients were evaluated and offered nimodipine therapy.

RESULTS:

Fifty-three patients were considered for treatment with nimodipine. Thirteen did not qualify for inclusion, 5 were lost to follow-up, and 7 had side effects requiring cessation of treatment. Thus 28 patients (30 paralyzed vocal folds) were analyzed. Eighteen of the paralyzed vocal folds experienced recovery of purposeful motion (60%). Historical controls and laryngeal electromyography meta-analysis suggest no more than a 20% recovery rate from AVFP.

CONCLUSIONS:

This open label study using nimodipine for treatment of AVFP demonstrates tripling of the recovery rate of vocal fold motion compared with historical controls. Further study in a randomized, controlled manner is warranted.

Copyright © 2013 Wiley Periodicals, Inc.

KEYWORDS:

laryngeal electromyography; laryngeal muscle innervation; nerve regeneration/drug effects; nimodipine; vocal cord paralysis

PMID:
24639294
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk