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Antimicrob Agents Chemother. 2014 Jun;58(6):3085-90. doi: 10.1128/AAC.02050-13. Epub 2014 Mar 17.

Molecular characterization of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in the countries of the Gulf cooperation council: dominance of OXA-48 and NDM producers.

Author information

  • 1The University of Queensland, UQ Centre for Clinical Research, Herston, Queensland, Australia King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia GCC Center for Infection Control, Riyadh, Saudi Arabia h.zowawi@uq.edu.au.
  • 2The University of Queensland, UQ Centre for Clinical Research, Herston, Queensland, Australia.
  • 3King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia GCC Center for Infection Control, Riyadh, Saudi Arabia.
  • 4The University of Queensland, UQ Centre for Clinical Research, Herston, Queensland, Australia Department of Medical Microbiology and Infectious Diseases, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom.
  • 5King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia Microbiology, Department of Pathology and Lab Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
  • 6University of Dammam, College of Medicine, Dammam, Saudi Arabia.
  • 7Zayed Military Hospital, Clinical Microbiology Department, Abu Dhabi, United Arab Emirates Pathology and Laboratory Medicine Department at Sheikh Khalifa General Hospital, Umm Al Quwain, United Arab Emirates.
  • 8Hamad Medical Cooperation, Clinical Microbiology Department, Doha, Qatar.
  • 9The Royal Hospital, Medical Microbiology Department, Muscat, Oman.
  • 10GCC Center for Infection Control, Riyadh, Saudi Arabia Department of Medicine, The Royal Hospital, Muscat, Oman.
  • 11GCC Center for Infection Control, Riyadh, Saudi Arabia Samlaniya Medical Complex, Infectious Diseases Unit, Manama, Bahrain.
  • 12Medical Laboratory Department, Faculty of Allied Health Sciences, Health Science Center, Kuwait University, Kuwait City, Kuwait.
  • 13The University of Queensland, UQ Centre for Clinical Research, Herston, Queensland, Australia Faculty of Medicine, Taif University, Taif, Saudi Arabia.
  • 14Microbiology Division, Mater Pathology, Brisbane, Queensland, Australia Molecular and Cellular Pathology Central Clinical Division, School of Medicine, University of Queensland, Brisbane, Queensland, Australia.

Abstract

The molecular epidemiology and mechanisms of resistance of carbapenem-resistant Enterobacteriaceae (CRE) were determined in hospitals in the countries of the Gulf Cooperation Council (GCC), namely, Saudi Arabia, United Arab Emirates, Oman, Qatar, Bahrain, and Kuwait. Isolates were subjected to PCR-based detection of antibiotic-resistant genes and repetitive sequence-based PCR (rep-PCR) assessments of clonality. Sixty-two isolates which screened positive for potential carbapenemase production were assessed, and 45 were found to produce carbapenemase. The most common carbapenemases were of the OXA-48 (35 isolates) and NDM (16 isolates) types; 6 isolates were found to coproduce the OXA-48 and NDM types. No KPC-type, VIM-type, or IMP-type producers were detected. Multiple clones were detected with seven clusters of clonally related Klebsiella pneumoniae. Awareness of CRE in GCC countries has important implications for controlling the spread of CRE in the Middle East and in hospitals accommodating patients transferred from the region.

Copyright © 2014, American Society for Microbiology. All Rights Reserved.

PMID:
24637692
[PubMed - in process]
PMCID:
PMC4068443
Free PMC Article
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