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A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis.
Cold Spring Harbor Laboratory, New York 11724.
The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.
PMID: 2463488 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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A noncoding RNA gene on chromosome 10p15.3 may function upstream of hTERT.
Miura N, Sato R, Tsukamoto T, Shimizu M, Kabashima H, Takeda M, Takahashi S, Harada T, West JE, Drabkin H, et al.
BMC Mol Biol. 2009 Feb 2; 10:5. Epub 2009 Feb 2.
[BMC Mol Biol. 2009]
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Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy.
Wang X, Kam Z, Carlton PM, Xu L, Sedat JW, Blackburn EH.
Epigenetics Chromatin. 2008 Oct 27; 1(1):4. Epub 2008 Oct 27.
[Epigenetics Chromatin. 2008]
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A diversity of uncharacterized reverse transcriptases in bacteria.
Simon DM, Zimmerly S.
Nucleic Acids Res. 2008 Dec; 36(22):7219-29. Epub 2008 Nov 12.
[Nucleic Acids Res. 2008]
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