Display Settings:

Format

Send to:

Choose Destination
Biochem Biophys Res Commun. 2014 Apr 4;446(2):448-53. doi: 10.1016/j.bbrc.2014.02.144. Epub 2014 Mar 12.

Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells.

Author information

  • 1Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address: 1138303166@qq.com.
  • 2Cancer Hospital of Jiangsu Province, Nanjing, Jiangsu, PR China. Electronic address: jianwei2010077@163.com.
  • 3Department of Oncology, Taizhou People' Hospital, Taizhou, Jiangsu, PR China. Electronic address: 2310848@163.com.
  • 4Department of Gastroenterology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address: 843039795@qq.com.
  • 5Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address: 2825636@qq.com.
  • 6Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address: 9111165@qq.com.
  • 7Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address: 1815857@qq.com.
  • 8Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address: 2376737@qq.com.
  • 9Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address: wkmys@sohu.com.

Abstract

Data derived from massive cloning and traditional sequencing methods have revealed that long non-coding RNAs (lncRNA) play important roles in the development and progression of cancer. Although many studies suggest that the lncRNAs have different cellular functions, many of them are not yet to be identified and characterized for the mechanism of their functions. To address this question, we assay the expression level of lncRNAs-Loc554202 in breast cancer tissues and find that Loc554202 is significantly increased compared with normal control, and associated with advanced pathologic stage and tumor size. Moreover, knockdown of Loc554202 decreased breast cancer cell proliferation, induced apoptosis and inhibits migration/invasion in vitro and impeded tumorigenesis in vivo. These data suggest an important role of Loc554202 in breast tumorigenesis.

Copyright © 2014 Elsevier Inc. All rights reserved.

KEYWORDS:

Breast cancer; Loc554202; lncRNA

PMID:
24631686
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk