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Clin Neurophysiol. 2014 Sep;125(9):1764-73. doi: 10.1016/j.clinph.2014.01.021. Epub 2014 Feb 10.

Eye closure causes widespread low-frequency power increase and focal gamma attenuation in the human electrocorticogram.

Author information

  • 1Department of Psychology, University of Pennsylvania, 19104, United States. Electronic address: aaron.geller@nyumc.org.
  • 2Neuroscience Graduate Group, University of Pennsylvania, 19104, United States.
  • 3Department of Neurology, Thomas Jefferson University, 19107, United States.
  • 4Department of Neurological Surgery, Thomas Jefferson University, 19107, United States.
  • 5Department of Neurology, University of Pennsylvania School of Medicine, 19104, United States.
  • 6Department of Neurosurgery, University of Pennsylvania School of Medicine, 19104, United States.
  • 7Department of Psychology, University of Pennsylvania, 19104, United States.

Abstract

OBJECTIVE:

We sought to characterize the effects of eye closure on EEG power using electrocorticography (ECoG). Specifically, we sought to elucidate the anatomical areas demonstrating an eye closure effect, and at which frequencies this effect occurs.

METHODS:

ECoG was recorded from 32 patients undergoing invasive monitoring for seizure focus localization. Patients were instructed to close and open their eyes repeatedly. ECoG power was compared in the epochs following eye closure and opening, for various frequency bands and brain regions.

RESULTS:

We found that at low frequencies, eye closure causes widespread power increases involving all lobes of the brain. This effect was significant not only in the α (8-12 Hz) band but in the δ (2-4 Hz), θ (4-8 Hz), and β (15-30 Hz) bands as well. At high frequencies, eye closure causes comparatively focal power decreases over occipital cortex and frontal Brodmann areas 8 and 9.

CONCLUSIONS:

Eye closure (1) affects a broad range of frequencies outside the α band and (2) involves a distributed network of neural activity in anatomical areas outside visual cortex.

SIGNIFICANCE:

This study constitutes the first large-scale, systematic application of ECoG to study eye closure, which is shown to influence a broad range of frequencies and brain regions.

Copyright © 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Alpha; ECoG; Event-related synchronization; Eye closure; Frontal eye fields; Gamma; High frequency activity; Intracranial EEG

PMID:
24631141
[PubMed - in process]
PMCID:
PMC4127381
[Available on 2015/9/1]
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