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Vet Parasitol. 2014 Apr 2;201(3-4):216-9. doi: 10.1016/j.vetpar.2014.02.017. Epub 2014 Mar 13.

Evaluation of the efficacy of afoxolaner against two European dog tick species: Dermacentor reticulatus and Ixodes ricinus.

Author information

  • 1Merial SAS, 29 Av Tony Garnier, 69007 Lyon, France. Electronic address: Pascal.dumont@merial.com.
  • 2Merial SAS, 29 Av Tony Garnier, 69007 Lyon, France.
  • 3ClinVet International, Universitas 9301, Bloemfontein, Free State, South Africa.
  • 4Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096, USA.


The acaricidal efficacy of a novel oral formulation of afoxolaner (NEXGARD(®), Merial) against two European tick species was assessed in dogs experimentally infested with Ixodes ricinus and Dermacentor reticulatus. Three studies, each characterized by a negative controlled randomized block design, were conducted with a total of 52 beagle or mongrel dogs of both sexes. Starting 2 days before treatment, each dog was infested weekly with approximately 50 ticks. The number of live ticks was counted at 48 h post-treatment (Day 2) as well as 48 h following each infestation on Days 9, 16, 23, and 30. Afoxolaner, administered at an average dose of 2.7 mg/kg bodyweight (range 2.5-2.9 mg/kg), rapidly eliminated the pre-existing tick infestations with over 99% acaricidal efficacy and controlled the weekly re-infestations for up to 30 days post treatment with over 96% efficacy on both tick species. Afoxolaner provides excellent acaricidal efficacy against these two major European tick species using the oral route of administration.

Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.


Afoxolaner; Dermacentor reticulatus; Dog; Ixodes ricinus; Tick

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