Description of a new experimental model skin flap for studying skin viability in rats

Acta Cir Bras. 2014 Mar;29(3):166-70. doi: 10.1590/S0102-86502014000300004.

Abstract

Purpose: To describe a new experimental flap for studying skin viability in rats.

Methods: Twenty male Wistar rats weighing between 250-300g were divided into two groups: group A - McFarlane technique, a 4 x 10cm flap was used (McFarlane); and in group B modified McFarlane technique, a 3 x 10cm flap was used. Seven days later, the animals were sacrificed and the area of necrosis was evaluated in both groups.

Results: Group A presented necrosis in 3% of the total area of the flap (CI: 0.01-0.05), Group B presented necrosis in 37% of the total area of the flap (CI: 0.29-0.46), (p<0.001).

Conclusion: The modified McFarlane flap presented a larger area of necrosis and could be an adequate experimental model of skin flap viability.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Male
  • Medical Illustration
  • Models, Animal*
  • Necrosis
  • Rats, Wistar
  • Reference Values
  • Reproducibility of Results
  • Skin / pathology*
  • Surgical Flaps / pathology*
  • Surgical Flaps / surgery
  • Tissue Survival*