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Am J Clin Pathol. 2014 Apr;141(4):573-83. doi: 10.1309/AJCPR92TDDFARISU.

CSF-1R expression in tumor-associated macrophages is associated with worse prognosis in classical Hodgkin lymphoma.

Author information

  • 1Dept of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Seoul 138-736, South Korea; jrhuh@amc.seoul.kr.

Abstract

OBJECTIVES:

The aim of this study was to determine the prognostic relevance of colony-stimulating 1 receptor (CSF-1R) expression in both Hodgkin/Reed-Sternberg (HRS) cells and the surrounding cells (non-HRS cells) in patients with classical Hodgkin lymphoma (CHL) .

METHODS:

Diagnostic tissues from 112 patients with CHL treated with doxorubicin, bleomycin, vinblastine, and dacarbazine were evaluated retrospectively by immunohistochemical analysis for CSF-1R and CD68 and CD163 for tissue-associated macrophages.

RESULTS:

High numbers (≥30%) of non-HRS cells expressing CSF-1R conferred inferior event-free survival and overall survival in univariate and multivariate analysis. High numbers of non-HRS cells expressing CSF-1R were significantly associated with a high number of tumor-associated macrophages as detected by CD163 expression (P < .001). In particular, coexpression of CSF-1R and CD163 was associated with a worse survival outcome than either CSF-1R or CD163 expression alone or no expression.

CONCLUSIONS:

Our data demonstrate that a high number of non-HRS cells expressing CSF-1R are correlated with an increased tumor macrophage content and worse survival.

KEYWORDS:

CD163; CD68; Colony-stimulating factor 1 receptor; Hodgkin lymphoma; Prognosis

PMID:
24619759
[PubMed - indexed for MEDLINE]
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