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Indian J Ophthalmol. 2014 Feb;62(2):246-8. doi: 10.4103/0301-4738.128635.

Recurrent progressive anterior segment fibrosis syndrome following a descemet-stripping endothelial keratoplasty in an infant with congenital aniridia.

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  • 1Department of Pediatric Ophthalmology and Adult Strabismus, Department of Cornea Services, Aditya Jyot Eye Hospital, Wadala, Mumbai, Maharashtra, India.


Progressive anterior segment fibrosis syndrome (ASFS), after intraocular surgery in older children (≥ 9 years) and adults with congenital aniridia, is described in the literature. In this report, we describe an unique case of ASFS in an infant with congenital aniridia following a combined trabeculotomy-ectomy and its recurrence after a descemet stripping endothelial keratoplasty. The ophthalmologists should be well aware of this entity and warn the parents about its possibilities. Use of immunomodulators or prolonged anti-inflammatory therapy may be considered to prevent its occurrence.

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