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    Biochem J. 1988 Oct 1;255(1):193-6.

    A monoclonal antibody to aromatic amino acid hydroxylases. Identification of the epitope.

    Cotton RG, McAdam W, Jennings I, Morgan FJ.

    Source

    Olive Miller Protein Laboratory, Murdoch Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.

    Abstract

    PH8 monoclonal antibody has previously been shown to react with all three aromatic amino acid hydroxylases, being particularly useful for immunohistochemical staining of brain tissue [Haan, Jennings, Cuello, Nakata, Chow, Kushinsky, Brittingham & Cotton (1987) Brain Res. 426, 19-27]. Western-blot analysis of liver extracts showed that PH8 reacted with phenylalanine hydroxylase from a wide range of vertebrate species. The epitope for antibody PH8 has been localized to the human phenylalanine hydroxylase sequence between amino acid residues 139 and 155. This highly conserved region of the aromatic amino acid hydroxylases has 11 out of 17 amino acids identical in phenylalanine hydroxylase, tyrosine hydroxylase and tryptophan hydroxylase.

    PMID:
    2461704
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC1135208
    Free PMC Article

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