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Pediatr Blood Cancer. 2014 Jun;61(6):1129-31. doi: 10.1002/pbc.24930. Epub 2014 Jan 13.

Establishing a high-risk neuroblastoma cohort using the Pediatric Health Information System Database.

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  • 1Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.


International Classification of Diseases, 9th Revision (ICD-9) code(s) for neuroblastoma do not exist, preventing identification of these patients in administrative databases. To overcome this challenge, a three-step algorithm, using ICD-9 codes, exclusion criteria, and manual review of chemotherapy billing data, was utilized to assemble a high-risk neuroblastoma cohort (n = 952) from the Pediatric Health Information System (PHIS) Database and validated at a single institution [sensitivity 89.1%; positive predictive value (PPV) 96.1%]. This cohort provides a data source for future comparative effectiveness and clinical epidemiology studies in high-risk neuroblastoma patients.

© 2014 Wiley Periodicals, Inc.


administrative database; cohort validation; neuroblastoma

[PubMed - indexed for MEDLINE]
[Available on 2015-06-01]
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