Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Transplant. 2014 May;14(5):1199-206. doi: 10.1111/ajt.12670. Epub 2014 Mar 10.

Single donor-derived strongyloidiasis in three solid organ transplant recipients: case series and review of the literature.

Author information

  • 1Department of Transplantation and Liver Surgery, Geisinger Medical Center, Danville, PA.

Abstract

Donor-derived Strongyloides stercoralis infections in transplant recipients are a rare but recognized complication. In this case series, we report donor-derived allograft transmission of Strongyloides in three solid organ transplant recipients. Following detection of infection in heart and kidney-pancreas recipients at two different transplant centers, a third recipient from the same donor was identified and diagnosed. S. stercoralis larvae were detected in duodenal aspirates, bronchial washings, cerebrospinal fluid, urine and stool specimens. Treatment with ivermectin and albendazole was successful in two of the three patients identified. The Centers for Disease Control and Prevention was contacted and performed an epidemiologic investigation. Donor serology was strongly positive for S. stercoralis antibodies on retrospective testing while all pretransplant recipient serum was negative. There should be a high index of suspicion for parasitic infection in transplant recipients and donors from endemic regions of the world. This case series underscores the need for expanded transplant screening protocols for Strongyloides. Positive serologic or stool tests should prompt early treatment or prophylaxis in donors and recipients as well as timely notification of organ procurement organizations and transplant centers.

© Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.

KEYWORDS:

Donor screening; Strongyloides; donor-to-host transmission; heart transplantation; renal and pancreas transplantation; renal transplant; strongyloidiasis; survivors; transplant infectious diseases

PMID:
24612907
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk