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J Arthroplasty. 2014 Feb 3. pii: S0883-5403(14)00074-6. doi: 10.1016/j.arth.2014.01.032. [Epub ahead of print]

The Effect of Osteoarthritis on 1-Year Risk of Ischemic Heart Disease Following Total Knee Arthroplasty.

Author information

  • 1Institution of Emergency and Critical Care Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Internal Medicine, Division of Cardiology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
  • 2Department of Internal Medicine, Division of Cardiology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
  • 3Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
  • 4Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
  • 5Institution of Emergency and Critical Care Medicine, National Yang-Ming University, Taipei, Taiwan.
  • 6School of Health Care Administration, Taipei Medical University, Taipei, Taiwan.

Abstract

To evaluate the long-term risk of ischemic heart disease (IHD) following total knee arthroplasty (TKA), we conducted a retrospective cohort study using data from the National Health Insurance Research Database of Taiwan. We evaluated 3599 primary TKA patients and 14,396 matched control patients. We further classified all patients into those with and without osteoarthritis (OA). The incidence rate of IHD was significantly higher among the TKA patients than among the matched control patients (1.13 vs 0.69 per 1000 person-months, P<.05). However, after controlling for OA, this difference was non-significant (HR=1.18, 95% confidence interval (CI): 0.63-2.20, P>.05). Our study results indicate that underlying OA conditions are predominantly responsible for increased long-term risk of IHD in TKA patients.

Copyright © 2014 Elsevier Inc. All rights reserved.

KEYWORDS:

ischemic heart disease; osteoarthritis; propensity score; total knee arthroplasty

PMID:
24612737
[PubMed - as supplied by publisher]
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