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Proc Natl Acad Sci U S A. 1988 Nov;85(21):7937-41.

Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters.

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  • 1Department of Pathology, Stanford University School of Medicine, CA 94305.

Abstract

During development cell types arise through the activation or repression of classes of specific genes. One hypothesis is that this phenomenon is realized by tissue-specific factors playing a role at the transcription level. Recently we have described a liver-specific nuclear protein, hepatocyte nuclear factor 1, that appears to be involved in the transcription of the fibrinogen and alpha 1-antitrypsin genes. In this report we describe the purification of hepatocyte nuclear factor 1 and demonstrate that it interacts with essential promoter regions of many liver-specific genes, including albumin, alpha-fetoprotein, and transthyretin. This finding suggests that hepatocyte nuclear factor 1 could be one factor necessary for establishing the liver phenotype. We also show that this protein binds to the promoter of the surface-antigen gene of the hepatitis B virus, a virus characterized by a high degree of hepatotropism.

PMID:
2460858
[PubMed - indexed for MEDLINE]
PMCID:
PMC282328
Free PMC Article
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