Format

Send to

Choose Destination
See comment in PubMed Commons below
Carbohydr Polym. 2014 Apr 15;104:231-7. doi: 10.1016/j.carbpol.2014.01.012. Epub 2014 Jan 10.

Chitosan-triphosphate nanoparticles for encapsulation of super-paramagnetic iron oxide as an MRI contrast agent.

Author information

  • 1Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
  • 2Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address: suchart@chiangmai.ac.th.
  • 3Nanodelivery System Laboratory, National Nanotechnology Center, National Science and Technology Development Agency, Pathumthani, 10120, Thailand.
  • 4Nanodelivery System Laboratory, National Nanotechnology Center, National Science and Technology Development Agency, Pathumthani, 10120, Thailand. Electronic address: warayuth@nanotec.or.th.

Abstract

Super-paramagnetic iron oxide nanoparticles (SPIONPs) were encapsulated at various concentrations within chitosan-triphosphate (SPIONPs-CS) nanoparticles using an ionotropic gelation method. The encapsulation of SPIONPs within CS nanoparticles enhanced their dispersion ability in aqueous solution, with all particles being lower than 130 nm in size and having highly positive surface charge. The SPIONPs-CS nanoparticles exhibited crystalline structure and super-paramagnetic behavior, as seen in non-encapsulated SPIONPs. The morphology of SPIONPs-CS nanoparticles showed that they almost spherical in shape. The effect of phantom environments (culture medium and 3% agar solution) on either T1 or T2 weighted MRI was investigated using a clinical 1.5T MRI scanner. The results revealed that 3% agar solution showed relaxation values higher than the culture medium, leading to a significant decrease in the MR image intensity. Our results demonstrated that the SPIONPs-CS nanoparticles can be applied as tissue-specific MRI contrast agents.

Copyright © 2014 Elsevier Ltd. All rights reserved.

KEYWORDS:

Chitosan; Chitosan-TPP nanoparticles; Encapsulation; Magnetic resonance imaging (MRI); Super-paramagnetic iron oxide nanoparticles

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk