Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Beilstein J Org Chem. 2014 Feb 14;10:405-24. doi: 10.3762/bjoc.10.38. eCollection 2014.

Continuous flow nitration in miniaturized devices.

Author information

  • 1Chem. Eng. & Proc. Dev. Division, CSIR-National Chemical Laboratory, Pune - 411 008, India, phone: +91-20-25902153.


This review highlights the state of the art in the field of continuous flow nitration with miniaturized devices. Although nitration has been one of the oldest and most important unit reactions, the advent of miniaturized devices has paved the way for new opportunities to reconsider the conventional approach for exothermic and selectivity sensitive nitration reactions. Four different approaches to flow nitration with microreactors are presented herein and discussed in view of their advantages, limitations and applicability of the information towards scale-up. Selected recent patents that disclose scale-up methodologies for continuous flow nitration are also briefly reviewed.


continuous flow; flow chemistry; microreactors; nitration; nitric acid; tubular reactor

Free PMC Article

Publication Types

Publication Types

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk