Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Indian Assoc Pediatr Surg. 2014 Jan;19(1):31-7. doi: 10.4103/0971-9261.125960.

Nonurological malignancies in children.

Author information

  • 1Department of Surgery, Division of Pediatric Surgery, King Fahd Hospital of the University, University of Dammam, Al Khobar, Saudi Arabia.

Abstract

CONTEXT:

Nonurological malignancies in children include a wide variety of tumors. These tumors include primary tumors of the liver, thyroid, lung, gastrointestinal tract (GIT), and adrenals; soft tissue sarcomas (STSs) like rhabdomyosarcoma (RMS) and non-RMS; and finally extragonadal germ cell tumors (GCT).

AIMS:

This article aims at describing the current thinking in the management of these childhood solid tumors. This is critical in view of the recent advances in the elucidation of the molecular, genetic, and biologic behavior of these tumors and how these factors are getting integrated not only in the staging but also in developing a risk-based approach towards the management of these tumors.

MATERIALS AND METHODS:

Reference was made to recently published literature from the leading pediatric cancer centers of the world to make a sense of things of the most current thinking in this rapidly expanding field. This will provide surgeons and physicians taking care of these children with a working knowledge in this somewhat challenging field.

CONCLUSIONS:

Treatment results vary from center to center depending on access to resources and following different management protocols. Results have improved for these tumors with the advent of newer chemotherapeutic agents, novel delivery methods of radiation therapy (RT), and improvement in surgical technique. Due to the limited number of patients presenting with these tumors, national and international collaboration of data is critical for all and beneficial to individual treatment centers. This has resulted in better results in the past and will definitely result in still better results in the future.

KEYWORDS:

Childhood; extragonadal germ cell tumor; hepatoblastoma; nonurological malignancies; pediatric solid tumor; rhabdomyosarcoma

PMID:
24604982
[PubMed]
PMCID:
PMC3935298
Free PMC Article

Publication Types

Publication Types

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
    Loading ...
    Write to the Help Desk