Format

Send to:

Choose Destination
See comment in PubMed Commons below
Urol Int. 2014;92(4):455-61. doi: 10.1159/000356175. Epub 2014 Feb 28.

Delay in nephrectomy and cancer control outcomes in elderly patients with small renal masses.

Author information

  • 1Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal, Canada.

Abstract

OBJECTIVE:

To examine the impact of nephrectomy delay on the survival of patients with small renal masses.

METHODS:

Relying on the Surveillance, Epidemiology, and End Results Medicare-linked database, 6,237 patients with pT1a renal cell carcinoma who underwent radical or partial nephrectomy were identified (1988-2005). Nephrectomy delay was dichotomized as ≤3 vs. >3 months. Uni- and multivariate Cox regression analyses tested the effect of delayed nephrectomy on cancer-specific mortality (CSM). In sub-analyses, various other time from diagnosis to nephrectomy cut-offs were modelled: (a) ≤1 vs. >1 month, (b) ≤2 vs. >2 months, (c) ≤4 vs. >4 months, (d) ≤6 vs. >6 months, (e) ≤12 vs. >12 months or (f) continuously coded.

RESULTS:

In univariate analyses, nephrectomy delay >3 months was associated with a higher risk of CSM (hazard ratio [HR]: 2.07; 95% confidence interval [CI]: 1.58-2.72; p < 0.001). However, after multivariate adjustment, a nephrectomy delay >3 months was not significantly associated with a higher risk of CSM (HR: 1.33; 95% CI: 0.96-1.86; p = 0.09). The lack of a relationship between nephrectomy delay and CSM after multivariate adjustment persisted even in various sub-analyses of other categorizations for nephrectomy delay.

CONCLUSIONS:

In the case of eventual nephrectomy delay among patients with small renal masses, CSM is unaffected.

© 2014 S. Karger AG, Basel.

PMID:
24602994
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland
    Loading ...
    Write to the Help Desk