Format

Send to:

Choose Destination
See comment in PubMed Commons below
Maturitas. 2014 Apr;77(4):380-4. doi: 10.1016/j.maturitas.2014.01.016. Epub 2014 Feb 15.

Selective estrogen receptor modulators (SERMs): new alternatives for osteoarthritis?

Author information

  • 1Bone and Joint Research Unit, Rheumatology Service, IIS Fundación Jiménez Díaz. Universidad Autónoma, Madrid, Spain. Electronic address: llugo@fjd.es.
  • 2Bone and Joint Research Unit, Rheumatology Service, IIS Fundación Jiménez Díaz. Universidad Autónoma, Madrid, Spain. Electronic address: avillalvilla@fjd.es.
  • 3Bone and Joint Research Unit, Rheumatology Service, IIS Fundación Jiménez Díaz. Universidad Autónoma, Madrid, Spain. Electronic address: rlargo@fjd.es.
  • 4Bone and Joint Research Unit, Rheumatology Service, IIS Fundación Jiménez Díaz. Universidad Autónoma, Madrid, Spain. Electronic address: gherrero@fjd.es.
  • 5Bone and Joint Research Unit, Rheumatology Service, IIS Fundación Jiménez Díaz. Universidad Autónoma, Madrid, Spain. Electronic address: jaromanblas@gmail.com.

Abstract

The dramatic rise in the prevalence rate of osteoarthritis (OA) after the menopause and the presence of estrogen receptors in joint tissues suggest that estrogen may help protect against the development of OA. Trials of estrogen therapy have produced inconclusive results, however, partly because of flaws in study design and partly because of the complexity of the mechanisms underlying estrogen's effects on joint tissues. Initial studies of the use of selective estrogen receptor modulators (SERMs) have reported beneficial effects in OA. These agents may exert both a direct effect upon joint cartilage and indirect effects on subchondral bone, synovium, muscle, tendons and ligaments. SERMs may be particularly beneficial for postmenopausal patients with osteoporotic OA, a phenotype defined by decreased bone density, associated with high remodeling in subchondral bone. More research is needed, though, before SERMs can become a therapeutic option for OA.

Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Estrogen receptors; Hormone therapy; Osteoarthritis; Selective estrogen receptor modulators

PMID:
24602552
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk